Methanol

Prophylactic Anti-diarrhoea Property of Chrysobalanus icaco Fruit Methanol Extract in Swiss Mice

Diarrhoea is one of the major health issues in the developing world due to poor water and sanitation. The methanol extract of the fruit of Chrysobalanus icaco (Coco plum) was evaluated for the prophylactic anti-diarrhoeal activity against castor oil-induced diarrhoea in Swiss mice. Diarrhoea was induced in the mice experimentally by castor oil administration, and the anti-diarrhoeal activity of various doses of the fruit extract (25, 50, and 100 mg/kg) was assessed against a control group and a reference group treated with loperamide (3 mg/kg).
AuthorName(s)
Gabriel, B.O
Chijindu, P.C
Iyamu, O.A
Ojoba, P.O
Oladimeji, T.B

Sub-acute Toxicity Assessment of Methanol Leaf Extract of Polyalthia longifolia (Sonn.) Thwaites on Haematological and In Vivo Antioxidant Parameters in Wistar Rats

Polyalthia longifolia is an ornamental plant, which has been reported to possess various ethnomedicinal applications. However, there is a dearth of information on the toxicity profile in the administration of the plant extract. The study evaluates the impact of sub-acute administration of methanol leaf extract of P.

AuthorName(s)
Timothy, O
Osayande, I.S.
Oghama, O.E

Effect of Aqueous and Methanolic Extract of Annona muricata Stem Bark on Liver Enzymes in Normal Sprague Dawley Rats

The use of plant extracts to treat diseases in herbal medicine has the potential of causing toxic effects, though of natural origin, it may not be safe. This study evaluated the effect of aqueous and methanolic extract of Annona muricata stem bark consumption in normal rats. Fresh stem bark of Annona muricata (Sour soup) was collected, pulverized, extracted with distilled water or methanol (Aqueous or Methanolic extract). The rats were divided into six (6) groups of five (5) rats per group, for aqueous or methanolic extract.

AuthorName(s)
Olumese, Fidelis E
Ukueku, Oghenerukevwe James
Orhue, Jerry N.2
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