The liver is a vital organ in the body that performs many functions. Many of these functions generate free radicals, which degenerate to loss of liver function. The antioxidants in the body neutralize the effect of the free radicals generated. The body is healthy when the antioxidants adequately neutralize free radicals. Carbon tetrachloride is usually used to model experimental liver damage in animals. This research investigated the possible protective and curative effect of the aqueous and ethanol extracts of Andrographis paniculata leaf on CCl4-induced liver damage in male rats.