Ameliorative Effects of a Polyherbal Formulation on Hepatic Function and Pancreatic Histomorphology in Streptozotocin-Induced Diabetic Male Wistar Rats
This study evaluated the ameliorative effects of a polyherbal formulation comprising Garcinia kola, Buchholzia coriacea, and Picralima nitida on hepatic function and pancreatic histomorphology in streptozotocin (STZ)-induced diabetic male Wistar rats. Thirty-five Wistar rats were randomly divided into seven groups: normal control, diabetic control, four groups treated with the polyherbal extract (100, 150, 200, and 250 mg/kg), and a positive control treated with metformin (50 mg/kg). Diabetes was confirmed 48 hours post-STZ injection (60 mg/kg).