Protective Functions of L-Arginine on Implantation in Pregnant Rats Administered L-NAME
Nitric oxide (NO) plays a role in estrogen-mediated uterine receptivity. We hypothesize that L-arginine a NO substrate will increase NO production and boost pregnancy outcomes in rats with inhibited NO synthase activity. Thirty-two pregnant rats were randomly divided into four groups, control (10 mL/kg of water), L-NAME (50 mg/kg), L-NAME + L-Arg (50 mg/kg and 500 mg/kg) and L-Arg only (500 mg/kg). L-Arg and L-NAME were administered orally and subcutaneously respectively from day 3-11 of pregnancy.