Ameliorative Action of the Extracts of Vernonia amygdalina and Dacryodes edulis on Alloxan-induced Necrosis of the Islet of Langerhans of Albino Wistar Rats
The global incidence of diabetes mellitus is increasing despite the availability of synthetic antidiabetic agents. This study evaluated the protective and regenerative effects of Vernonia amygdalina and Dacryodes edulis aqueous leaf extracts on pancreatic beta-cell damage in alloxan-induced diabetic Wistar rats. Thirty-six male rats were randomized into six groups (n = 6). Group 1 was the normal control, while Groups 2–6 were alloxan-induced (150 mg/kg i.p.). Group 2 was the negative control, Group 3 received metformin (200 mg/kg), Groups 4 and 5 were treated with V. amygdalina and D.