Phyllanthus amarus

Methanolic extracts of the leaves of Phyllanthus amarus and stem of Phyllanthus muellerianus were studied for antileishmaniasis activity, phytotoxicity and cytotoxicity. The antileishmanial activity was evaluated in vitro using promastigote culture of Pakistani leishmanial strain (L. major) in 96 well micro titer plate bioassay, while phytotoxicity was assessed using the Lemna bioassay and cytotoxicity using brine shrimp lethality assay. Methanolic extract of stem of P.

Malaria infestation in Nigeria is still worrisome, hence, the need for new antimalarial agents. This study, therefore, investigates the antiplasmodial activity of the ethanolic extract and flavonoid fraction of the stem of P. amarus in the blood, brain, liver and pancreas of Plasmodium berghei (chloroquine sensitive NK65 strain) infested mice.