Normal Diet and Linoleic-Enriched Sunflower Oil Improved Sperm Variables but Not Reproductive Hormones in Male Wistar Rats

admin — Fri, 04 Aug 2023 20:44:39 +0000

Normal Diet and Linoleic-Enriched Sunflower Oil Improved Sperm Variables but Not Reproductive Hormones in Male Wistar Rats admin Fri, 08/04/2023 - 20:44

Male reproductive processes are impacted by edible fats. The present work studied the effect of the consumption of a sunflower-enriched diet on sperm variables and reproductive hormones in male rats. A total of twenty male Wistar rats were used in this study. The Control group received the regular rat chow while the Treated group received the regular rat chow supplemented with 25% linoleic sunflower oil. After 28 days sperm variables, and reproductive hormones were assessed. There was no significant difference in the serum testosterone and prolactin levels in the group fed sunflower-enriched diet compared to the control group. The serum LDH and the seminal vesicle fructose levels were significantly increased in the animals fed sunflower enriched diet compared to the control animals. The sperm count and sperm motility levels were significantly higher in the rats fed sunflower enriched diet compared to the control rats. The current findings imply that while 25% linoleic sunflower oil might increase sperm characteristics, it might not have the same effect on testosterone levels.

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Year Of Publication

2023

Volume

Page Range

169-173

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Normal Diet and Linoleic-Enriched Sunflower Oil Improved Sperm Variables but Not Reproductive Hormones in Male Wistar Rats - PDF

Protective Functions of L-Arginine on Implantation in Pregnant Rats Administered L-NAME

admin — Thu, 02 Mar 2023 17:50:51 +0000

Protective Functions of L-Arginine on Implantation in Pregnant Rats Administered L-NAME admin Thu, 03/02/2023 - 17:50

Nitric oxide (NO) plays a role in estrogen-mediated uterine receptivity. We hypothesize that L-arginine a NO substrate will increase NO production and boost pregnancy outcomes in rats with inhibited NO synthase activity. Thirty-two pregnant rats were randomly divided into four groups, control (10 mL/kg of water), L-NAME (50 mg/kg), L-NAME + L-Arg (50 mg/kg and 500 mg/kg) and L-Arg only (500 mg/kg). L-Arg and L-NAME were administered orally and subcutaneously respectively from day 3-11 of pregnancy. Blood samples were collected on day 8 for the assay of nitric oxide, TNF-α and interleukin-10 concentrations. The rats were sacrificed on day 12 of pregnancy. L-NAME-administered rats had decreased maternal body weight and number and weight of implantation sites when compared with the control (p< 0.05). Co-administration of L-NAME with L-Arg significantly increased the body weights and fetal weights when compared with L-NAME. L-Arginine co-administration with L-NAME significantly boosted NO and interleukin-10 concentrations and significantly reduced TNF-α concentration when compared with L-NAME. Malondialdehyde (MDA) level was significantly reduced while activities of superoxide dismutase (SOD) and catalase (CAT) increased in the L-NAME + L-Arg group compared with L-NAME only group. The study reveals that L-arginine improves fetal development through its antioxidant and anti-inflammatory actions.

Year Of Publication

2022

Volume

Page Range

284-291

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