Antimalarial Activity of Extracts and Partially Purified Fractions of Alstonia boonei De Wild

admin — Sat, 05 Aug 2023 03:57:34 +0000

Antimalarial Activity of Extracts and Partially Purified Fractions of Alstonia boonei De Wild admin Sat, 08/05/2023 - 03:57

Alstonia boonei De wild is famed for several bioactive properties; this study measures its in vivo antimalarial potentials as well as phytochemical, nutritional and antioxidant properties. Variants of its stem bark extract were screened for phytochemical, nutritional and antioxidant properties using established procedures. In vivo antimalarial properties of extracts and fractions were determined against Plasmodium berghei NK65 infection in mice using chemo-suppressive, prophylactic, curative and mean survival time (MST) bioassays. Alkaloids, saponins, cardiac glycosides, tannins, flavonoids and phenolics were present in almost all extracts. The plant contained nitrogen free extract (NFE), crude fat, crude protein, moisture, crude ash and crude fibre in reasonable amounts. Extracts demonstrated antioxidant activity against DPPH and ferrous ion radicals. The aqueous and ethanol extracts were more active, decreased parasitaemia and increased MST relative to infected untreated control in the chemo-suppressive and prophylactic bioassays. Solvent-solvent partitioning of the hydro-ethanol extract yielded petroleum ether, dichloromethane-DCM, basified-DCM (BDCM), acidified-DCM (ADCM) and aqueous fractions. BDCM had the highest suppressive activity (70.91% suppression; MST: 16.50 ± 1.19), while the crude extract had the highest prophylactic (64.51% suppression; MST: 16.00 ± 1.22) and curative activities (69.80% suppression; MST: 16.80 ± 0.58). Alstonia boonei De wild possesses antimalarial properties likely associated with its phyto-nutritional composition.

Year Of Publication

2023

Volume

Page Range

305-317

AuthorName(s)

Kissinger Obaogie Orumwensodia

Patrick Ojeifo Uadia

Keyword(s)

Alstonia boonei De wild

Issue Number

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Antimalarial Activity of Extracts and Partially Purified Fractions of Alstonia boonei De Wild

Diet Composition and Dynamics in Fish Species of Ogun Coastal Water, Southwest, Nigeria

Department of Zoology and Environmental Biology, Olabisi Onabanjo University, Ago-Iwoye, Ogun State, Nigeria

Assessment of Prolonged Administration of SynriamTM on Haematological Parameters and Lipid Profiles of Rats

admin — Sat, 05 Aug 2023 03:18:57 +0000

Assessment of Prolonged Administration of SynriamTM on Haematological Parameters and Lipid Profiles of Rats admin Sat, 08/05/2023 - 03:18

A potential antimalarial prospect should have high efficacy with low toxicity. SynriamTM antimalarial drug has been proven to be safe and effective for the treatment of malaria in human with dearth information on rats. This study investigated its potential toxicity from prolonged administration on lipid profiles and haematological indices in rats. Thirty-five Wistar rats were randomized into five groups (A – E) of seven rats each. Animals in group A (control) received 0.5 mL distilled water, while groups B, C, D, and E respectively received 4.0, 8.0, 16.0 and 32.0 mg/kg bwt of the drug once daily for 28 days. The concentrations of serum TC, LDL and atherogenic index showed significant (p<0.05) decrease, while serum TRIG, HDL, and VLDL concentrations had no effect (p>0.05). The drug also had no effect (p>0.05) on the levels of the red blood cell count, PCV, Hb, MCV, MCH, and MCHC. Similarly, it had no effect (p>0.05) on the levels of the WBC, lymphocytes and neutrocytes, while the platelet counts had slight (p<0.05) decrease. Hence, SynriamTM is relatively safe at doses of 4.0-32.0 mg/kg bwt in rats when taken once daily with minimal effects on the lipid profiles and haematological indices.

Year Of Publication

2023

Volume

Page Range

245-254

AuthorName(s)

David Chukwuma Nwikwe

Elizabeth Abidemi Balogun

Keyword(s)

Antimalarial

Arterolane malate

Piperaquine phosphate

SynriamTM

Toxicity

Issue Number

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Assessment of Prolonged Administration of SynriamTM on Haematological Parameters and Lipid Profiles of Rats - PDF