A potential antimalarial prospect should have high efficacy with low toxicity. SynriamTM antimalarial drug has been proven to be safe and effective for the treatment of malaria in human with dearth information on rats. This study investigated its potential toxicity from prolonged administration on lipid profiles and haematological indices in rats.
The study was to determine the level of toxicity of repeated administration of ethanol extract of a medicinal mushroom, Daldinia concentrica in animal model. Wistar albino rats of both sexes were sorted randomly into four groups of five rats each. Graded doses of 200, 400 and 800 mg/kg of the extract were administered orally, once daily for eight consecutive days to the rats in the respective groups, while control group received 10% tween 80 in distilled water only.
The effect of the ethanol extract of Aloe barbadensis root on selected serum biochemical parameters was investigated.Sixty male Wistar rats were randomly selected and administered 100, 200 and 400 mg/kg of the extract and 0.2ml/kg of distilled water (control) for 14 days. The results of the liver marker enzymes revealed that there were non-significant changes (p>0.05) in alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels on days 1, 7 and 14 of treatment.
