The toxicity of sickle cell anaemia maintenance drugs makes medicinal plants viable alternatives. The protective roles of Moringa oleifera (MO) parts (Bark, flower, leaf, root and seed) against phenylhydrazine (PHZ) induced spleen toxicity and oxidative stress in rats were carried out. Splenomegaly was observed in anaemic rats and was reversed by M. oleifera parts, particularly the flower and roots. The M. oleifera leaves significantly reduced the elevated malondialdehyde levels to that of control rats, control rats (NOR) 4.66±0.14, anaemic rat (NEG) 10.81±0.60, hydroxyurea treated group (HU) 8.25±0.53 and M. oleifera leaves (MOL) 4.59±0.1. The increase in GPx and decrease in CAT observed in the anaemic rat's spleen were returned to the control value by MOL, while MOR ameliorated the GPx only. The histopathology analysis of the various treatment groups' spleen tissues corroborated the biochemical results. The results indicated that various parts of MO, particularly the leaf, attenuated the toxic effects of phenylhydrazine on the spleen. MOL can thus serve as a natural source of non-toxic sickle cell anaemia care nutraceuticals.