Attenuative Benefits of Leaf Extract of Annona muricata in Alloxan-Induced Diabetic Mice

The methanol extract of Annona muricata leaf was investigated for its effects on blood glucose, haematology, serum electrolyte and kidney parameters of alloxan-induced diabetic mice. Six groups of mice (5 mice per group) was used for this study. Group A served as “Normal control” and fed mice pellets and water. Diabetes was induced in Groups B, C, D, and E by intraperitoneal injection of alloxan (90 mg/kg). Group C were treated with glibenclamide (5 mg/kg body weight), group D, E,and F received 250 mg/kg, 500 mg/kg and 1000 mg/kg body weight of extract daily respectively for 21 days via oral gavage.Group B mice were induced but not treated with any drug, thus it served as the “Negative control” group. The extract significantly (p>0.05) lowered the fasting blood glucose level in alloxan induced diabetic mice. The effect of diabetes on Group B 18.50 was significantly low in the final body weight (kg) of the mice compared to group C, D, E and F (51.69, 33.54, 29.23 and 33.40) which were increased. However, the group A (45.02) remained healthy throughout the study period. The extract 
showed significantly improved haemoglobin (Hb) values in the treatment groups compared to the diabetic untreated groups. The findings from this study suggest that methanol leaf extract of A. muricata demonstrated better anti-diabetic agents in mice and may be of immense benefits in the management of diabetes and its associated complications.