Histopathological Evaluation of the Effects of Vitamin C on Cisplatin-induced testicular damage in Wistar albino Rats
Cisplatin is a very effective chemotherapeutic agent used in treating various types of cancer, but its application may have damaging effects on testicular morphology. In this study, the effect of vitamin C, a known antioxidant, on cisplatin-induced testicular damage was investigated. Thirty Wistar rats were grouped into six groups (A-F) of five rats per group. Cisplatin was given as a single dose of 8 mg/kg body weight 24 hours prior to daily vitamin C administration at l00 mg and 200 mg respectively, for two weeks in 2 ml distilled water by gastric gavage.