Chinedu-Ndukwe, P.A

The toxicity of hair dressing salon effluent on Clarias gariepinus juveniles was studied using static bioassay method. This study investigated haematological, histopathological and biochemical changes in Clarias gariepinus juveniles. The fish samples were distributed randomly into T1 (800 ml/L), T2 (600 ml/L), T3 (400 ml/L), T4 (200 ml/L), and T5 control (water alone). All samples were studied in three replicates, in a completely randomized experiment. Mortality increased with  increased effluent concentrations; 250.96 ml/L was recorded as LC50 for 96 h.

The methanol extract of Annona muricata leaf was investigated for its effects on -cell dysfunction, and  atherogenenic dyslipidaemia in alloxan-induced diabetic mice. Thirty (30) mice of both sexes, aged between 8-10 weeks were randomly divided into normal, diabetic, diabetic + glibenclamide(5mg/kg), diabetic+250 mg/kg A. muricata Extract, diabetic+500 mg/kg A. muricata Extract, diabetic+1000 mg/kg A. muricata Extract, groups (n=6/group). Alloxan was administered intraperitoneally while extracts and glibenclamide were given via oral route for 21 days.

The methanol extract of Annona muricata leaf was investigated for its effects on blood glucose, haematology, serum electrolyte and kidney parameters of alloxan-induced diabetic mice. Six groups of mice (5 mice per group) was used for this study. Group A served as “Normal control” and fed mice pellets and water. Diabetes was induced in Groups B, C, D, and E by intraperitoneal injection of alloxan (90 mg/kg).