Cisplatin is an established chemotherapeutic substance commonly used in the treatment of cancer. This study was conducted to examine the possible counter effects of Human Menopausal Gonadotropins (HMG) against testicular toxicity induced by Cisplatin in male rats. 20 adult male rats were equally divided into four groups; A, B, C and D which were the control, Cisplatin, HMG and Cisplatin+HMG groups respectively.
Cisplatin is a very effective chemotherapeutic agent used in treating various types of cancer, but its application may have damaging effects on testicular morphology. In this study, the effect of vitamin C, a known antioxidant, on cisplatin-induced testicular damage was investigated. Thirty Wistar rats were grouped into six groups (A-F) of five rats per group. Cisplatin was given as a single dose of 8 mg/kg body weight 24 hours prior to daily vitamin C administration at l00 mg and 200 mg respectively, for two weeks in 2 ml distilled water by gastric gavage.
Cisplatin is a very effective chemotherapeutic agent used in treating various types of cancer, but its application may have damaging effects on testicular morphology. In this study, the effect of vitamin C, a known antioxidant, on cisplatin-induced testicular damage was investigated. Thirty Wistar rats were grouped into six groups (A-F) of five rats per group.
