Heart

The study aimed to evaluate the biosafety of “Makann”, an aqueous bi-herbal formulation of the root extract of Garcinia kola and Carica papaya (BH) on the heart and lungs of adult female albino mice. Garcinia kola and Carica papaya roots were harvested, prepared into a bi-herbal extract (BH), and administered to the test group while the control group received distilled water. Mice were divided into 3 test groups and 3 control groups of 5 animals: single dose 24 h test groups, single-dose 14-day test group, and daily dose 14-day test group.

The heart is a vital organ of the body that pumps blood through the aorta and its branches which provide blood flow to all organs and tissues of the body. Any injury causes distortion of the smooth functioning of the cardiovascular system. This study investigated the histological changes in the heart and aorta of Wistar rats following exposure to cement dust. Twenty-four (24) Wistar rats weighing between 250 g and 280 g were divided into 4 groups of 6 rats per group.