Joy Okpuzor

Therapeutic reactivation of foetal haemoglobin (HbF) can alleviate clinical complications associated with sickle cell anaemia (SCA), a severe monogenic disorder that is prevalent in sub-Saharan Africa. Traditional medicine practitioners in Nigeria utilize the stem bark of Theobroma cacao as a haematinic for SCA patients, but its potential to induce HbF remains uncertain.

The toxicity of sickle cell anaemia maintenance drugs makes medicinal plants viable alternatives. The protective roles of Moringa oleifera (MO) parts (Bark, flower, leaf, root and seed) against phenylhydrazine (PHZ) induced spleen toxicity and oxidative stress in rats were carried out. Splenomegaly was observed in anaemic rats and was reversed by M. oleifera parts, particularly the flower and roots. The M.