This study was conducted with the aim of studying the variations by sex and genotype in morphometry of the Oropharyngeal Cavity in Nigerian indigenous chickens. Avian mouth and pharynx do not show any definite line of demarcation, but constitute a common Oropharyngeal Cavity. Generally, anatomical structures found in the dorsal wall of the oropharynx include the palate, choanal slit, and infundibulum, while structures in the ventral wall of the Oropharynx include a concave depression between the rami of the lower beak, laryngeal mound and glottis. Thirty apparently healthy adult indigenous chickens were purchased from local market in Mokwa, quarantined, stabilized, slaughtered, de-feathered and the heads were collected for morphometric studies. The width, length and thickness of structures in the Oropharyngeal cavity parameters were used for this study. The data obtained were expressed as Mean ± SEM and subjected to statistical analysis using Multivariate Analysis of Variance at 95% Confidence Interval (CI). Values of [P≤0.5] were considered significant. There was no significant interaction between sex and genotype on the combined dependent variables, Wilks' Λ = 0.00, F (36, 2) = 3.495, p = 0.247; multivariate η2=0.984. The main effects of sex and genotype were not significant, Wilks' Λ = 0.03, F (18, 1) = 17.334, p = 0.187; multivariate η2=0.997 and Wilks' Λ = 0.01, F (36, 2) = 1.635, p = 0. 452; multivariate η2=0.9676 respectively. This indicates that linear composite of the combined dependent variables does not differ between Male and Female chickens and across the genotypes. The mean lengths, thicknesses and widths of upper beak at commissure at the transverse row of papillae of three genotypes studied were significantly different from one another (P<0.05) except the lower beak at lateral side (P
0.05). This study also established a base line data for further oropharyngeal cavity in these three genotypes of Nigerian indigenous chicken.