Joseph Omorogiuwa Erhabor

This study evaluated the ameliorative effects of a polyherbal formulation comprising Garcinia kola, Buchholzia coriacea, and Picralima nitida on hepatic function and pancreatic histomorphology in streptozotocin (STZ)-induced diabetic male Wistar rats. Thirty-five Wistar rats were randomly divided into seven groups: normal control, diabetic control, four groups treated with the polyherbal extract (100, 150, 200, and 250 mg/kg), and a positive control treated with metformin (50 mg/kg). Diabetes was confirmed 48 hours post-STZ injection (60 mg/kg).

Diarrhoeal diseases remain a global health challenge, with rising antimicrobial resistance driving the need for plant-based therapies. This study evaluated the phytochemical composition and anti-diarrhoeal activity of a bi-herbal aqueous extract derived from Psidium guajava and Ocimum gratissimum. The phytochemical analyses were performed using standard methods. The in vitro anti-diarrhoeal activity of the extract was assessed against selected diarrhoeagenic microorganisms (Escherichia coli, Salmonella sp., Shigella dysenteriae, and Aspergillus niger) using the agar well diffusion technique.