Sleep Deprivation-Induced Rat Medial Prefrontal Cortex DNA oxidation, TNF-α, and IL-1β Upregulation is Mitigated with Probiotics
Lifestyle-induced stress and the abuse of antibiotics are among the causes of mental health problems. This
study was designed to determine if supplementation with probiotics (Probio) can significantly mitigate the effect of
paradoxical sleep deprivation (PSD) on the medial prefrontal cortex (mPFC) neurochemistry and redox status. Adult male
Wistar rats were randomized into seven groups (n = 5/group) comprising the control, acute PSD; acute Probio, acute
PSD+Probio, chronic PSD, chronic Probio, and chronic PSD+Probio groups.