Behavioural patterns of rats in an open field following treatment with Artesunate plus Amodiaquine combination
Artesunate (AS) plus amodiaquine (AQ) combination is a potent artemisinin-base antimalrial drug is commercially available with different trade names. Several adverse effects including neurotoxic complaints have been ascribed to this combination. This study was to determine the behavioral pattern of rats treated with this drug in an open field. Forty matured male Wistar rats weighing 150-180g were equally grouped into four. Group A was the control and the animals received tap water placebo, while groups B, C and D were the experimental.