Onuoha, M. C.

Hypoglycemic, Hematologic and Hypolipidemic Potential of Hippophae rhamnoides (Berry Oil) in Alloxan-induced Diabetic Rats

This study was carried out to evaluate the hypoglycemic, hematologic and hypolipidemic potential of berry oil in alloxan-induced adult Wistar rat. Five groups of Wistar rats (4 rats per group) Group 1 served as “Normal control” rats and received normal rat pellets and water. Diabetes mellitus was induced in Groups 2, 3, 4, and 5 by intraperitoneal injection of alloxan (160 mg/kg). Group 3 rats were treated with glibenclamide (5 mg/kg body weight), groups 4 and 5 received 500 mg/kg and 1000 mg/kg body weight of Berry oil daily respectively for 21 days via oral gavage.