Osarenren, E.J

Streptozotocin (STZ) is a chemical compound known to damage pancreatic β-cells and cause hyperglycemia. Hyperglycemia plays a key role in glomerular, mesangial cell, and tubular damage in kidneys. Metabolic dysregulation, including hyperglycemia, initiates cellular damage in the kidneys. The present study investigated the modulatory effect of aqueous extract of Dialium guineense (AEDG) stem bark on oxidative status of diabetic rat kidneys.

Oxidative stress is implicated in the pathogenesis of diseases, such that drugs with strong antioxidant property are promoted for health management. The present study evaluated the modulatory effect of aqueous extract of Dialium guineense (AEDG) stem bark on oxidative status of diabetic rat liver. Adult male rats (Wistar strain, n = 20, mean weight = 165 ± 15 g) were randomly assigned to four groups (5 rats/group): control, diabetic, metformin, and extract groups. Diabetes mellitus (DM) was induced in the rats via intraperitoneal injection of streptozotocin (STZ, 50 mg/kg body weight, bwt).