Bioactive compounds

This study evaluated the ameliorative effects of a polyherbal formulation comprising Garcinia kola, Buchholzia coriacea, and Picralima nitida on hepatic function and pancreatic histomorphology in streptozotocin (STZ)-induced diabetic male Wistar rats. Thirty-five Wistar rats were randomly divided into seven groups: normal control, diabetic control, four groups treated with the polyherbal extract (100, 150, 200, and 250 mg/kg), and a positive control treated with metformin (50 mg/kg). Diabetes was confirmed 48 hours post-STZ injection (60 mg/kg).

Medicinal plants contain rich phytochemicals, and antioxidant compounds that affect physiological functions, fighting diseases related to inflammation and pains. They also have influence against bacteria, fungi, and parasites that cause several ailments. Parinari excelsa is a medicinal plant which belongs to the family of Chrysobalanaceae. In this study, Parinari excelsa seed was extracted with n-haxane through Soxhlet extraction method, concentrated with rotary evaporator to obtain the extract.