Effects of Ethanol Extract of Musa Paradisiaca on Kidney Biomarkers in Aspirin-Induced Ulcerated Wistar Rats

The effect of ethanol extract of unripe M. paradisiaca on kidney biomarkers was investigated in an ulcerated rat model. A total of twenty-four (24) rats, randomly divided into six (6) groups, were acclimatized for 14 days and subsequently subjected to ulcer induction using aspirin (225 mg/200 g b. wt). The groups included a normal control, negative control, three groups treated with 200, 40 and 800 mg/kg b. wt. of M. paradisiaca, respectively and a positive control group administered omeprazole (5 mg/kg b. wt.). Extract administration lasted for 5 days and some kidney function parameters were evaluated. Results show that administration of the ethanol extract significantly enhanced the relative weight of the kidney comparable to the group administered the standard as there was no significant differences between these groups (p > 0.05). There were no significant differences in the total protein, creatinine and electrolyte levels in the ulcerated rats compared to the normal control (p > 0.05) and administration of the extract had no effect on the concentrations of these parameters. Furthermore, there was a significant decrease in the urea levels compared to the normal control (p < 0.05) and treatment with the extract (200 mg/kg b. wt.) reversed the ulcer-induced increase in urea levels. The result buttresses the safety of the extract as it did not alter the electrolyte and kidney biomarker concentration.