Arachis hypogaea Seeds Reduced Glucose Metabolism in Colon of Rats Exposed to 1,2-Dimethylhydrazine

The aim of this study was to ascertain the effects of peanut diet supplementation on glucose metabolism in rats exposed to 1, 2-dimethylhydrazine. Lactate dehydrogenase and glucose -6-phosphate dehydrogenase activities were used as indices for glucose metabolism. Eighty-four rats of both sexes were used for this study and were divided into seven groups of 6 rats each. 1, 2- dimethylhydrazine (DMH) was administered subcutaneously at a dose of 25 mg/kg body weight.Group A rats were maintained on rat feed, group B rats were maintained on rat feed and administered DMH once weekly for 12 weeks. The group C rats were administered DMH weekly for 24 weeks while on normal diet. Group D rats were administered DMH and feed for 12 weeks followed by peanut supplemented diet for the next 12 weeks. The group E rats received DMH weekly and peanut supplemented diet for 24 weeks while group F rats had peanut supplemented diet for 12 weeks before the administration of DMH for 12 weeks. Group G rats were maintained on only peanut supplemented diet for 24 weeks. Relative to the control and diet supplemented groups, Lactate dehydrogenase and Glucose-6-phosphate dehydrogenase activities were significantly (p ≤ 0.05) increased in the colon of the DMH-only treatment group. Thus, increased glucose consumption occasioned by the exposure to DMH can be altered by the peanut supplementation in the diets of exposed rats.