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Antibacterial Efficacy of Carica papaya (Pawpaw) Seeds against Some Clinical Bacterial Isolates

The increase in antibacterial resistance has led to the urgent need for novel therapeutic agents, and recently, plant-based antibacterials have emerged as a promising substitute. This study aimed to investigate the antibacterials activity of the aqueous and ethanol extracts of the Carica papaya seeds against Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, and Staphylococcus aureus. C. papaya seeds were collected, dried, and ground into powder, followed by the extraction of their bioactive compounds using water and ethanol solvents.

Human Parvovirus B19-Induced Anaemia among Febrile In-Patient Paediatrics in Benin Metropolis, Edo State, Nigeria

Human Parvovirus B19 (B19V) is a highly contagious pathogen that causes amongst others transient aplastic anaemia in infected individuals. This study investigated febrile inpatient paediatrics for the presence of human parvovirus B19 infection. In this cross-sectional study, 150 consenting febrile paediatrics (90 males and 60 females) admitted into the paediatric hospital wards were recruited. The sera obtained from the participants were screened for B19V IgM antibodies. The model (forest plot) explained a 9% prevalence among the study participants.

Investigating Hepatitis B Co-Infection in COVID-19 Patients in a National Teaching Hospital in Southern Nigeria

Hepatitis B virus (HBV) remains a significant global health issue, particularly in regions with high endemicity. With the advent of the COVID-19 pandemic, understanding the intersection of HBV infection and COVID-19 is crucial. This study investigated the prevalence and impact of pre-existing HBV infection among COVID-19 patients in Benin City, Edo State, Nigeria. This single-center cross-sectional study was conducted at the University of Benin Teaching Hospital.

Anti-hyperlipidemic Effect, Growth Performance and in vivo Antioxidant Enhancements of Launaea taraxacifolia Leaf-based Diet in High-fat Diet-induced Hyperlipidemic Rats

The study investigated the anti-hyperlipidemic activity, in-vivo antioxidant and growth performance enhancements of Launaea taraxacifolia leaf-based diet at 6.25% , 12.5% and 25% inclusion levels in high-fat diet-induced hyperlipidemic rats. 36 female rats weighing 165.82 ± 2.10g were assigned into two groups: A (6) and B (30). Animals in group B were made hyperlipidemic by feeding on high-fat diet for six weeks and confirmed by assaying for lipid profile, body weight gain (BWG), body mass index (BMI) and hip circumference (HC).

Phthalate Esters in Raw and Finished Water from Drinking Water Treatment Plants and Human Exposure in Songkhla, Southern Thailand

The presence of phthalate esters (PEs) in water treatment facilities has drawn a lot of interest because of the possible health risks. This research provide data on 6 PEs in the raw and finished water of three waterworks located in Songkhla Province, southern Thailand. Given that drinking water is a major way that people can be exposed to PEs, the fate of target PEs in the three conventional drinking water treatment plants was also analyzed.

Occurrence and Human Health Risk Assessment of Phthalate Esters in Sediments from a Riverine in Southern Thailand

Phthalate esters (PAEs) are environmentally active organic pollutants that can cause endocrine disruption in humans. This study evaluated the human health risk associated with the dermal exposure to the levels of six common PAEs in sediments collected from U-Tapao River. A gas chromatograph/mass spectrometer (GC–MS) analytic method was used for the identification and quantification of PAEs. The human health risk was carried out using hazard quotient (HQ) and hazard index (HI).

Hormonal Contraceptives Use and Serum Alpha-Fetoprotein Level among Women Accessing Family Planning Clinics in Ogbomoso South Local Government Area, Nigeria

Hormonal contraceptives are widely used, but their effects on liver health and cardiovascular risk factors are not fully understood. This study examined hormonal contraceptive (HC) effects on liver health (serum alpha-fetoprotein, AFP), anthropometrics, and blood pressure in 72 women (40 HC users, 32 non-users). A descriptive cross–sectional study design was conducted over seven months on 72 women attending family planning clinics in Ogbomoso South Local Government Area, Oyo State, Nigeria.

Acute Toxicity Studies and In Vitro Effects of Guiera senegalensis (Sabara) Leaf Aqueous Extract on Trypanosoma brucei

Trypanosomes are a type of protozoan that is spread by the bite of an infected tsetse fly and causes nagana in animals and African trypanosomiasis (also known as sleeping sickness) in people. The purpose of this study was to identify the phytochemical components and acute lethal dose of Guiera senegalensis and to study the effects of its leaf aqueous extract on Trypanosoma brucei. Standard analysis methods were used in this study. Aside the acute toxicity (LD50) test, both the phytochemical and the anti-trypanosomal potential of Guiera senegalensis were carried out in-vitro.

Evaluating Psidium guajava (Guava) Leaf Extracts Ability to Improve Biochemical and Haematological Indices in Anaemic Rats

Psidium guajava (Guava) leaf is used to cure a variety of illnesses, including cough, gastrointestinal pain, gastroenteritis, diarrhea and inflammatory conditions. This study aimed to determine the effect of aqueous extract of Psidium guajava leaf on biochemical and haematological parameters on phenylhydrazine-induced rat. Twenty-Five male Wistar rats, aged between 8 – 10 weeks, were divided into five groups of five rats per group.

Ameliorative Action of the Extracts of Vernonia amygdalina and Dacryodes edulis on Alloxan-induced Necrosis of the Islet of Langerhans of Albino Wistar Rats

The global incidence of diabetes mellitus is increasing despite the availability of synthetic antidiabetic agents. This study evaluated the protective and regenerative effects of Vernonia amygdalina and Dacryodes edulis aqueous leaf extracts on pancreatic beta-cell damage in alloxan-induced diabetic Wistar rats. Thirty-six male rats were randomized into six groups (n = 6). Group 1 was the normal control, while Groups 2–6 were alloxan-induced (150 mg/kg i.p.). Group 2 was the negative control, Group 3 received metformin (200 mg/kg), Groups 4 and 5 were treated with V. amygdalina and D.