Cytokines

Sleep Deprivation-Induced Rat Medial Prefrontal Cortex DNA oxidation, TNF-α, and IL-1β Upregulation is Mitigated with Probiotics

Lifestyle-induced stress and the abuse of antibiotics are among the causes of mental health problems. This study was designed to determine if supplementation with probiotics (Probio) can significantly mitigate the effect of paradoxical sleep deprivation (PSD) on the medial prefrontal cortex (mPFC) neurochemistry and redox status. Adult male Wistar rats were randomized into seven groups (n = 5/group) comprising the control, acute PSD; acute Probio, acute PSD+Probio, chronic PSD, chronic Probio, and chronic PSD+Probio groups.
AuthorName(s)
Leke Jacob Medubi
Oluwatoyin Ojuolape Medubi
Boluwatife Oluwajuwon Owolabi
Gamaliel Afoluwajuwonlo Obaoye
Abraham A.A. Osinubi

Combination of Aspartame and Acesulfame Potassium Does not Alter Blood Glucose, Lipids and Cytokines of Female Rats

 The use of combination of artificial sweeteners, most importantly aspartame (E951) and acesulfame potassium (E950) in foods, beverages and other products is on the increase despite reports on their side effects. This study investigated the effects of combination of tolerable daily dose of both aspartame and acesulfame-k on blood glucose, lipids and cytokines of female Wistar rats. Twenty-five female Wister rats weighing 90.7±8.1 g were randomly assigned into five groups.

AuthorName(s)
Ibitoye, Oluwayemisi Beatrice
Usman, Maryam
Tanimowo, Oluwayemisi Bukola
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