Garcinia kola,

The study aimed to evaluate the biosafety of “Makann”, an aqueous bi-herbal formulation of the root extract of Garcinia kola and Carica papaya (BH) on the heart and lungs of adult female albino mice. Garcinia kola and Carica papaya roots were harvested, prepared into a bi-herbal extract (BH), and administered to the test group while the control group received distilled water. Mice were divided into 3 test groups and 3 control groups of 5 animals: single dose 24 h test groups, single-dose 14-day test group, and daily dose 14-day test group.

This research determines the antibacterial activity of the aqueous and methanol root extracts of male and female Carica papaya and Garcinia kola individually and in biherbal formulations using the agar diffusion method. The dried roots of the two plants were powdered separately. Garcinia kola (100 g) and Carica papaya (100 g) were macerated separately in boiled water and absolute methanol, Garcinia kola (50 g) and Carica papaya (50 g) were combined (100 g) and macerated in boiled water and absolute methanol at room temperature (30°C ± 2°C) for 72 hours.