Macdonald Idu

The study aimed to evaluate the biosafety of “Makann”, an aqueous bi-herbal formulation of the root extract of Garcinia kola and Carica papaya (BH) on the heart and lungs of adult female albino mice. Garcinia kola and Carica papaya roots were harvested, prepared into a bi-herbal extract (BH), and administered to the test group while the control group received distilled water. Mice were divided into 3 test groups and 3 control groups of 5 animals: single dose 24 h test groups, single-dose 14-day test group, and daily dose 14-day test group.

Over years, Crossopteryx febrifuge leaf has been used as curative without knowing its antioxidant and nutritional properties. Antioxidant properties were determined using some standard methods. Proximate analysis of carbohydrates, protein, crude fibers and crude fat as well as some mineral and vitamin compositions were also determined using standard methods in Association of Official Analytical Chemists. It was found that the plant exhibited significant free radical scavenging activity and have significant phenol and flavonoid contents.

This research determines the antibacterial activity of the aqueous and methanol root extracts of male and female Carica papaya and Garcinia kola individually and in biherbal formulations using the agar diffusion method. The dried roots of the two plants were powdered separately. Garcinia kola (100 g) and Carica papaya (100 g) were macerated separately in boiled water and absolute methanol, Garcinia kola (50 g) and Carica papaya (50 g) were combined (100 g) and macerated in boiled water and absolute methanol at room temperature (30°C ± 2°C) for 72 hours.