Oxidative stress

Sleep Deprivation-Induced Rat Medial Prefrontal Cortex DNA oxidation, TNF-α, and IL-1β Upregulation is Mitigated with Probiotics

Lifestyle-induced stress and the abuse of antibiotics are among the causes of mental health problems. This study was designed to determine if supplementation with probiotics (Probio) can significantly mitigate the effect of paradoxical sleep deprivation (PSD) on the medial prefrontal cortex (mPFC) neurochemistry and redox status. Adult male Wistar rats were randomized into seven groups (n = 5/group) comprising the control, acute PSD; acute Probio, acute PSD+Probio, chronic PSD, chronic Probio, and chronic PSD+Probio groups.
AuthorName(s)
Leke Jacob Medubi
Oluwatoyin Ojuolape Medubi
Boluwatife Oluwajuwon Owolabi
Gamaliel Afoluwajuwonlo Obaoye
Abraham A.A. Osinubi

Effect of Acute Administration of Ethanol Extract of Cannabis sativa Leaf on Oxidative Stress Biomarkers in Male and Female Wistar Rats

 Oxidative stress is a phenomenon caused by an imbalance between production and accumulation of oxygen reactive species (ROS) in the cells and tissues and the ability of a biological system to detoxify these reactive products. This study investigated the acute effect of different doses of ethanolic extract annabis sativa (EECS) on oxidative stress biomarkers in male (M) and female (F) Wister rats.

AuthorName(s)
A.F. Odetayo
O.J. Deborah1, N.H. Aishat
M.E. Balogun
O.E. Ayoola
Amuda Oluwasola
E.B. Mariam
O.J. Adekunle
A.M. Comfort
V.J. Nkemdili
S.O. Zainab
S.O. Zainab
S.S. Muzzammill

Phytochemical and Proximate Evaluation of Fresh and Spoilt Fruits of Tomatoes (Solanum lycopersicum L.) Sold in Five Major Markets in Benin City, Edo State, Nigeria

Deparment of Plant Biology & Biotechnology, Faculty of Life Sciences, University of Benin, Benin City

Protective Effect of Rutin and Vitamin E on Cobalt Chloride Induced Neurotoxicity

Toxic exposures to cobalt chloride could occur from dietary, occupational, and medical sources. This study evaluated the ameliorative effect of oral administration of rutin and vitamin E on cobalt chloride (CoCl2)-induced oxidative stress in the brain of rats following exposure to cobalt chloride (CoCl2) toxicity. Wistar rats were randomly divided into five groups. Group 1 received only water, while group 2 received cobalt chloride (300 ppm) in drinking water.

AuthorName(s)
Ebunoluwa Racheal Asenuga
Ademola Adetokunbo Oyagbemi
Temitayo Olabisi Ajibade
Omolola Victoria Awoyomi
Temidayo Olutayo Omobowale
Blessing Seun Ogunpolu

Association of Total Antioxidant Capacity Status and Malondialdehyde with C-Reactive Protein Levels in Bronze Foundry Workers in Benin City, South-South, Nigeria

Occupational exposure to bronze borne toxicant is entirely unregulated in many countries. The foundry industry is known to contain a lot of toxic metals and the exposure of foundry workers to these metals may result in prooxidant/antioxidant imbalance and can act as an intermediate in the formation of an oxidative stress state. This aim of this study was to investigate the levels of total antioxidant capacity, malondialdehyde and C-reactive protein among bronze foundry workers in Benin City, South-South Nigeria.

AuthorName(s)
O.G. Igharo
O.E. Osakue
E.U. Anyaluore
E.L. Igharo
J.O. Osakue
J.O. Osunbor
B.O. Eiya
S.A. Owie
C.I. Owie
G.A. Aikpitanyi-Iduitua
A.I. Aruomaren
I.H. Igbinosa
O.S. Imadiyi

Selected Biochemical Parameters and Oxidative Stress Status of Rats Administered Antimalaria Herbal Extract – ‘Agbo’

Herbs are increasingly used across the globe; In fact, the World Health Organization reported that most African countries, including Nigeria, depend on herbal medicines for primary health care, without much documented evidence of adverse effects. Agbo polyhebral extract is popular in Nigeria, especially among (but not limited to) the local populace of the southwestern areas. The aim of this study is to determine the effects of malaria alcoholic herbal extract (Agbo) on renal, liver, oxidative stress markers and hematological parameters on wistar rats.

AuthorName(s)
Bibiana Omozee Eiya*
Osaretin Godwin Igharo

Selected Biochemical Parameters and Oxidative Stress Status of Rats Administered Antimalaria Herbal Extract – ‘Agbo’

Herbs are increasingly used across the globe; In fact, the World Health Organization reported that most African countries, including Nigeria, depend on herbal medicines for primary health care, without much documented evidence of adverse effects. Agbo polyhebral extract is popular in Nigeria, especially among (but not limited to) the local populace of the southwestern areas. The aim of this study is to determine the effects of malaria alcoholic herbal extract (Agbo) on renal, liver, oxidative stress markers and hematological parameters on wistar rats.

AuthorName(s)
Bibiana Omozee Eiya
Osaretin Godwin Igharo
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