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Dexamethasone is a glucocorticoid, often prescribed for various inflammatory and immunological disorders. However, its role in promoting cardiometabolic risk has been widely reported. This study investigated the ameliorative effects of letrozole on dexamethasone-induced cardiometabolic disorder in rats. Twenty male Wister rats were randomly divided into control, letrozole (1 mg/kg, p.o), dexamethasone (0.2 mg/kg, p.o) and dexamethasone + letrozole groups.

Phyllanthus amarus is a highly medicinal plant with its therapeutic activities spanning a wide scope of diseases and ailments. Earlier literatures indicated the effectiveness of this plant in combating hepatitis, malaria, diabetes, and cancer. In the present study the effect of ethanol extract of P. amarus on colon cancer in Swiss albino mice induced by 1, 2 dimethylhydrazine (DMH) was investigated. 15 female Swiss mice of weight 25-35g were acclimatized for a week and randomized into 3 groups (5 per group). Group A (-DMH), Group B (DMH, 300mg/kg body weight of ethanol extract of P.