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Dexamethasone is a glucocorticoid, often prescribed for various inflammatory and immunological disorders. However, its role in promoting cardiometabolic risk has been widely reported. This study investigated the ameliorative effects of letrozole on dexamethasone-induced cardiometabolic disorder in rats. Twenty male Wister rats were randomly divided into control, letrozole (1 mg/kg, p.o), dexamethasone (0.2 mg/kg, p.o) and dexamethasone + letrozole groups.

Phyllanthus amarus is a highly medicinal plant with its therapeutic activities spanning a wide scope of diseases and ailments. Earlier literatures indicated the effectiveness of this plant in combating hepatitis, malaria, diabetes, and cancer. In the present study the effect of ethanol extract of P. amarus on colon cancer in Swiss albino mice induced by 1, 2 dimethylhydrazine (DMH) was investigated. 15 female Swiss mice of weight 25-35g were acclimatized for a week and randomized into 3 groups (5 per group). Group A (-DMH), Group B (DMH, 300mg/kg body weight of ethanol extract of P.

This study assessed the toxicity of water-soluble fractions of petrol on Chlorella vulgaris and Scenedesmus obliquus. Water soluble fractions of petrol were prepared into various concentrations as follows: 0%, 5%, 10%, 25%, 50%, 75% and 100%. These treatments were inoculated with 5 mL of the test microalgae and read at 750 nm at two-day intervals for 14 days using a UV/VIS Spectrophotometer.

Therapeutic reactivation of foetal haemoglobin (HbF) can alleviate clinical complications associated with sickle cell anaemia (SCA), a severe monogenic disorder that is prevalent in sub-Saharan Africa. Traditional medicine practitioners in Nigeria utilize the stem bark of Theobroma cacao as a haematinic for SCA patients, but its potential to induce HbF remains uncertain.

The phenological study provides a detailed comparison of life cycles of six species of Euphorbia with a view to enhancing the knowledge of the taxonomic status of the genus. Growth and developmental stages were investigated using pot experiments. Description of six principal growth stages was done and these include leaf development, shoot development, flowering emergence, fruit development, seed ripening and seed dispersal. All the investigations were carried out for 77 days under the same experimental conditions.

This study presents an assessment of the influence of urban runoff on fish fauna in the Ikpoba River, Nigeria, focusing on heavy metal contamination and gill pathology in benthic (Clarias gariepinus) and pelagic (Oreochromis niloticus) fish species. Samples of water, sediment, and fish gills were collected from June to August 2023. Heavy metals (Ni, Co, Cr, Pb, and Cd) were analyzed via Atomic Absorption Spectrometry (AAS), and gill pathology was evaluated through histopathological examination.

The surge in human exposure to heavy metals, driven by their widespread industrial use, demands a thorough examination of their toxicity. This study focuses on heavy metal contamination in canned fish sold in Benin City, with an emphasis on Atlantic bluefin tuna, Atlantic mackerel, and European pilchard. Six brands of canned fish were purchased from selected markets in Benin City, Nigeria, and the heavy metal levels were assessed using Atomic Absorption Spectrophotometry (AAS) instrumentation.

The fermented and non-fermented seed powder of Vitis vinifera, a herbaceous plant with numerous biological activities was investigated in this study. The pH, in vitro antimicrobial assay against Staphylococcus aureus, Escherichia coli, and Candida albicans, phytochemical, proximate compositions were screened, while the active compounds of the fermented sample were further evaluated by High-performance liquid chromatography (HPLC). A decline in pH from 6.2 to 3.6 was recorded during fermentation for 14 days.

This research investigates the impact of atrazine, a widely used herbicide, on the reproductive capabilities of adult Clarias gariepinus, a freshwater catfish of ecological and economic significance. Twelve months old specimens of C. gariepinus comprising of twenty (20) males and twenty (20) females with mean average weight of 1024 ± 88.4g and 1100 ± 97.4g respectively and mean total length of 52.8 ± 2.3cm and 52.7 ± 1.1cm respectively, were exposed to exposed to four different sub-lethal concentrations of atrazine (40µg/L, 60µg/L, 80µg/L, and 100µg/L) in a semi-static renewal assay.