African Scientist Volume 26 , Issue 1 ,2025

Phyllanthus amarus is a highly medicinal plant with its therapeutic activities spanning a wide scope of diseases and ailments. Earlier literatures indicated the effectiveness of this plant in combating hepatitis, malaria, diabetes, and cancer. In the present study the effect of ethanol extract of P. amarus on colon cancer in Swiss albino mice induced by 1, 2 dimethylhydrazine (DMH) was investigated. 15 female Swiss mice of weight 25-35g were acclimatized for a week and randomized into 3 groups (5 per group). Group A (-DMH), Group B (DMH, 300mg/kg body weight of ethanol extract of P.

Dexamethasone is a glucocorticoid, often prescribed for various inflammatory and immunological disorders. However, its role in promoting cardiometabolic risk has been widely reported. This study investigated the ameliorative effects of letrozole on dexamethasone-induced cardiometabolic disorder in rats. Twenty male Wister rats were randomly divided into control, letrozole (1 mg/kg, p.o), dexamethasone (0.2 mg/kg, p.o) and dexamethasone + letrozole groups.

The global incidence of diabetes mellitus is increasing despite the availability of synthetic antidiabetic agents. This study evaluated the protective and regenerative effects of Vernonia amygdalina and Dacryodes edulis aqueous leaf extracts on pancreatic beta-cell damage in alloxan-induced diabetic Wistar rats. Thirty-six male rats were randomized into six groups (n = 6). Group 1 was the normal control, while Groups 2–6 were alloxan-induced (150 mg/kg i.p.). Group 2 was the negative control, Group 3 received metformin (200 mg/kg), Groups 4 and 5 were treated with V. amygdalina and D.

Psidium guajava (Guava) leaf is used to cure a variety of illnesses, including cough, gastrointestinal pain, gastroenteritis, diarrhea and inflammatory conditions. This study aimed to determine the effect of aqueous extract of Psidium guajava leaf on biochemical and haematological parameters on phenylhydrazine-induced rat. Twenty-Five male Wistar rats, aged between 8 – 10 weeks, were divided into five groups of five rats per group.

Trypanosomes are a type of protozoan that is spread by the bite of an infected tsetse fly and causes nagana in animals and African trypanosomiasis (also known as sleeping sickness) in people. The purpose of this study was to identify the phytochemical components and acute lethal dose of Guiera senegalensis and to study the effects of its leaf aqueous extract on Trypanosoma brucei. Standard analysis methods were used in this study. Aside the acute toxicity (LD50) test, both the phytochemical and the anti-trypanosomal potential of Guiera senegalensis were carried out in-vitro.

Hormonal contraceptives are widely used, but their effects on liver health and cardiovascular risk factors are not fully understood. This study examined hormonal contraceptive (HC) effects on liver health (serum alpha-fetoprotein, AFP), anthropometrics, and blood pressure in 72 women (40 HC users, 32 non-users). A descriptive cross–sectional study design was conducted over seven months on 72 women attending family planning clinics in Ogbomoso South Local Government Area, Oyo State, Nigeria.

Phthalate esters (PAEs) are environmentally active organic pollutants that can cause endocrine disruption in humans. This study evaluated the human health risk associated with the dermal exposure to the levels of six common PAEs in sediments collected from U-Tapao River. A gas chromatograph/mass spectrometer (GC–MS) analytic method was used for the identification and quantification of PAEs. The human health risk was carried out using hazard quotient (HQ) and hazard index (HI).

The presence of phthalate esters (PEs) in water treatment facilities has drawn a lot of interest because of the possible health risks. This research provide data on 6 PEs in the raw and finished water of three waterworks located in Songkhla Province, southern Thailand. Given that drinking water is a major way that people can be exposed to PEs, the fate of target PEs in the three conventional drinking water treatment plants was also analyzed.

The study investigated the anti-hyperlipidemic activity, in-vivo antioxidant and growth performance enhancements of Launaea taraxacifolia leaf-based diet at 6.25% , 12.5% and 25% inclusion levels in high-fat diet-induced hyperlipidemic rats. 36 female rats weighing 165.82 ± 2.10g were assigned into two groups: A (6) and B (30). Animals in group B were made hyperlipidemic by feeding on high-fat diet for six weeks and confirmed by assaying for lipid profile, body weight gain (BWG), body mass index (BMI) and hip circumference (HC).